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Thursday, November 19, 2020 | History

2 edition of Studies on age-related changes in human cortical bone. found in the catalog.

Studies on age-related changes in human cortical bone.

Edward Donald Simmons

Studies on age-related changes in human cortical bone.

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Published .
Written in English


The Physical Object
Pagination112 leaves
Number of Pages112
ID Numbers
Open LibraryOL19539809M

(spongy bone) this makes up only 20% of the skeleton. it is found within the ends of the long bones. it is aligned in a precise network of columns that protect the bone from extreme stress. this bond is more susceptible of osteoporosis because it is more sensitive to changes in hormones and nutritional factors, this bone is being broken down and replenished at any given . Start studying KINS (Types of Bone). Learn vocabulary, terms, and more with flashcards, games, and other study tools. Materials and Methods. Human subject studies were institutional review board approved and HIPAA compliant; informed consent was obtained. Cortical BW concentration was determined with custom-designed MR imaging sequences at T and was validated in sheep and human cortical bone by using exchange of native water with deuterium oxide (D 2 O). The Cited by:


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Studies on age-related changes in human cortical bone. by Edward Donald Simmons Download PDF EPUB FB2

Cortical thickness slightly decreases with aging. Although most studies emphasize the important role of trabecular bone in age-related vertebral fragility, both old and new studies point to an important role for the cortical shell, particularly when trabecular bone volume is low, in elderly subjects [ 24 – 27 ].Cited by: Although age-related changes in cancellous bone structure in human are relatively well characterized, few studies have addressed changes in cortical bone.

We have investigated age-related changes in iliac crest bone biopsy specimens from 54 normal subjects, 23 men and 31 women, aged 18–90 by: 8. In the past two decades, studies of human specimens using imaging techniques have revealed decreased bone strength in older adults compared with younger adults.

The present paper addresses recently. The developing human brain: age‐related changes in cortical, subcortical, and cerebellar anatomy, Brain and Behavior, ; 6 (4), e, doi: /brb Notes [Correction added on 03 Mayafter first online publication: “The” was inserted in the article title, so it reads as “The developing human brain: Age‐related Cited by: The objective of this study was to investigate age-related changes in noncalcified collagen molecules in osteoid and its likely effects on the mechanical integrity of human cortical bone.

Thirty human cadaveric femurs were divided into three age groups: young adults, middle age, and the elderly, by: Bone status can be evaluated on all organizational levels (cell -* tissue --* intact organ) in AGE-RELATED BONE CHANGES Fig.

The age-related development of cortical porosities is shown in representative cross-sectional views of the femur midshaft from 6-(A), (B), and 24(C)-month-old male rats.

Original magnification approximately x Cited by: Growth and Age-Related Abnormalities in Cortical. cortical bone of human femur in the elderly at different loca- Bone physiology and age-related bone changes. Chapter. In this study, the morphological characteristics of the cortical bone in human femoral diaphysis samples were analyzed from individuals who lived before bisphosphonate drugs were available in Japan.

A total of 90 right femoral bones were arbitrarily selected (46 males and 44 females) from modern Japanese skeletal : Takeshi Imamura, Toshiyuki Tsurumoto, Kazunobu Saiki, Keita Nishi, Keishi Okamoto, Yoshitaka Manabe. of human bone, considerably less on age changes in the mechanical properties of human bone, and least of all on the inter- relations of age, mechanical properties and histology or biochemistry of human bone.

Uehira (’60) reported that both the com- pressive and the tensile strength of corti- cal bone from adult Japanese subjects de. Actions of denosumab on cortical and trabecular bone. Results from this head to head studies and the difference in the mode of action of denosumab compared to bisphosphonates, suggested a difference in their effect on the diverse compartments of bones (cortical and trabecular).

This was further explored in a 3-year sub-study of the FREEDOM trial. We examined the in vitro strength and toughness properties of hydrated human cortical bone samples from diaphyses of fresh-frozen humeri from young and old groups (young, 34–41 y old, N = 7; aged, 85–99 y old, N = 6).

Middle-aged bone (61–69 y old, N = 5) was additionally evaluated for toughness by:   In this study we examined the age-related changes in the cortical and trabecular bone in old age, and assessed whether we can find evidence of Cited by: 3. resorption. The aim of the present study was to assess age related changes in long bone cortical bone measurements in ancient Egyptian males and females.

Materials and methods The study skeletons were kept in a storeroom at Giza and belong to the Old Kingdom period (– B.C.), which is known as the period of pyramid builders ( In this study, four-point bending fatigue tests were conducted on aging human bone (age 26 to 89) in conjunction with histological evaluation of the resultant tensile (diffuse damage) and compressive (linear microcracks) damage to identify the damage morphologies associated with an increase in age-related bone by: Metacarpal cortical bone mass was measured in healthy Japanese men aged 40–95 years, using a microdensitometer to determine age-related changes in cortical bone in these middle-aged and elderly men.

Total bone mass showed a significant negative correlation with age (r = −; P Cited by:   In order to ascertain whether the intrinsic strength of human bone changes with age or not, we have determined the ultimate tensile strength and density of strips of femoral cortical bone.

These femora were collected from cadavers varying in age from 13 to 97 years. The results show that both density and intrinsic strength of bone increase up to about the Cited by:   The structure of human cortical bone evolves over multiple length scales from its basic constituents of collagen and hydroxyapatite at the nanoscale to osteonal structures at near-millimeter dimensions, which all provide the basis for its mechanical properties.

To resist fracture, bone’s toughness is derived intrinsically through plasticity (e.g., fibrillar sliding) at structural Cited by: To describe data from digital radiogrammetry (DXR) in an unselected German female cohort over a wide age range. Using a retrospective study design we analyzed radiographs of the hand from German women (aged 5–96 years) using an automated assessment of cortical thickness, metacarpal index (MCI), and estimated cortical bone mineral density (DXR-BMD) on digitized Cited by:   The mechanism of age-related cortical bone loss was investigated in Japanese women, 41–94 years of age, by metacarpal bone mass measurement.

While no significant correlation was found between bone width and age, a significant increase in bone marrow width, and significant decreases in cortical bone density and total bone mass were Cited by: Studies have demonstrated that androgens influence growth plate maturation and closure (thus helping to determine longitudinal bone growth during development) mediate regulation of cortical bone mass in a fashion distinct from estrogen (leading to a sexually dimorphic skeleton, modulate peak bone mass acquisition), and influence trabecular.

The aim of the present study was to assess age related changes in long bone cortical bone measurements in ancient Egyptian males and females.

Material and methods: The material of. density of human cortical bone, bovine cortical bone and simulated cortical bone which has the same mechanical characteristics as bone. The results from these measurements can then be used to improve the models that are currently being used to determine the effect of applied temperature differences on human bone.

Age-Related Changes in the Biochemical Properties of Human Cancellous Bone Collagen: Relationship to Bone Strength.

a special focus is placed on human cortical bone elastic properties both at. Histomorphometric data on age-related changes in cortical bone in men are sparse. In addition, skeletal heterogeneity of changes is likely to be particularly evident as a result of differences in the weight-bearing properties at different sites, resulting in site-specific differences in the onset and rate of age-related bone by: Rasoulian et al.

() studied age-related changes in porcine femoral cortical bone and showed that the IDI decreases with age in developing bone. In their studies. Chatterji, S., Wall, J.C., Jeffery, J.W.: Age-related changes in the orientation and particle size of the mineral phase in human femoral cortical bone.

Calcif. Tissue Int. 33 (6), – () CrossRef Google ScholarCited by: 6. @article{osti_, title = {Age-related changes in the plasticity and toughness of human cortical bone at multiple length-scales}, author = {Zimmermann, Elizabeth A and Schaible, Eric and Bale, Hrishikesh and Barth, Holly D and Tang, Simon Y and Reichert, Peter and Busse, Bjoern and Alliston, Tamara and Ager, III, Joel W and Ritchie, Robert O}, abstractNote = {The structure of human Cited by: Figure 1: Age-related change in the fatigue life of human cortical bone subjected to bending fatigue.

Each point in the figure represents an average of two specimens obtained from the anterior and posterior cortex of tibial diaphysis. The analysis of. Using the gradient of human cortical bone properties to determine age-related bone changes via ultrasonic guided waves Cécile Barona,∗ a Aix-Marseille Univ, ISM,Marseille, France CNRS, UMR, Marseille, France Abstract Bone fragility depends not only on bone mass but also on bone quality (structure and material).

Human cortical bone is a nanocomposite of collagen molecules and hydroxyapatite (HA) nanocrystals. However, its essential mechanical properties of stiffness (ca. 15–25 GPa), strength (ca. MPa), and toughness (≥5 MPa/m) † are not derived solely from the characteristic structure at the nanoscale, but rather at multiple length scales through bone’s.

CLINICAL RELEVANCE This study provides information concerning the difference in properties of cortical bone tissue as a function of donor age. The importance of changes in porosity, reflected by changes in the density of bone, will allow investigators to use non-invasive means to estimate the mechanical properties of cortical bone in by:   As trabecular bone comprises only 20% of the whole skeleton, even though trabecular loss is more rapid than cortical bone loss, the slower loss of cortical bone, which comprises 80% of the skeleton, results in similar absolute amounts of cortical and trabecular bone loss during the first 10 years after menopause; an observation that is contrary Cited by: Cortical Bone.

Human bone is composed of two fundamental compartments: cortical bone and trabecular bone. 11, 12 Cortical bone makes up approximately 80% of the skeletal mass of an adult human 13 and is primarily found in the shaft of long bones formed as a shell around the trabecular bone.

It can withstand much greater load than trabecular Cited by:   In adult bone, plane strain modulus was in the range of 7 to 35 22,23,24,25 and cortical bone stiffness is predominantly associated with mineral content and bone density while cortical bone Cited by: 1.

The areas of the brain that experience the most dramatic changes with age are also among the last to mature in adolescence. This has led scientists to propose a “last in, first out” theory of brain aging – the last parts of the brain to develop are the first to deteriorate.

Studies of age-related changes to white matter support this. Studies of bone histomorphometry in rabbits demonstrate that trabecular bone forms both trabecular and cortical bone of the metaphyseal region.

13 Studies of bone microarchitecture in baboons demonstrate that ∼60% of the variation in cortical bone microstructure is accounted for by genetic factors. 24, 25 Likewise, studies in human subjects Cited by: Mineralized tissues, such as bone and tooth dentin, serve as structural materials in the human body and, as such, have evolved to resist fracture.

In assessing their quantitative fracture resistance or toughness, it is important to distinguish between intrinsic toughening mechanisms which function Cited by: 7. Age-related losses in bone mineral density (BMD), muscle strength, balance, and gait have been linked to an increased risk of falls, fractures and disability, but few prospective studies have compared the timing, rate and pattern of changes in each of these measures in middle-aged and older men and women.

This is important so that targeted strategies can be Cited by: Human bone has a complex hierarchical microstructure 6,7,8,9 that can be considered at many dimensional scales 6, the shortest length-scale, it is composed of type-I Cited by: Age-Related Changes inCortical andCancellous Vertebral Bone Density inGirls:Assessment with Quantitative CT StefanoMora1’2 William n3 oro1 1 James Sayre3 Vicente Gilsanz1 OBJECTIVE.

Bonemassincreases duringgrowth, butlittleinformation Isavailable aboutthechanges incortical andcancellous bonedensities duringskeletal. cortical bone is a dynamic, living tissue that has a complex and continuously evolving microstructure that changes throughout life.

Cortical bone morphology has been identified as an important aspect of the overall bone quality as it contributes significantly to mechanical properties of bone ().A vital component of the cortical bone microstructure is a canal network, the Cited by: Characterization of Cortical Bone Thickness Changes in the Human Ribs with Age and Sex Sarah K.

Lynch, Ashley A. Weaver, Samantha L. Schoell, Joel D. Stitzel Wake Forest University, Winston-Salem, NC Abstract This study characterized age and sex-related changes in rib cortical thickness to study the effect on thoracic injury risk.concentration in bone and to find the influence of the human subject age on the results.

Due to the fact that previous studies showed high differences in bones metals concentrations relative to the sex, living area and bone type we used in this study only male human bones, from the same area (Bucharest) and the same bone type (cortical).